Subject Guides: Epilepsy: Landmark Articles

Medical Management

Early identification of refractory epilepsy.
N Engl J Med. 2000 Feb 3;342(5):314-9.
Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs: A 30-Year Longitudinal Cohort Study.
JAMA Neurol. 2018;75(3):279-286. doi:10.1001/jamaneurol.2017.3949
Drug-resistant epilepsy.
N Engl J Med. 2011 Sep 8;365(10):919-26. doi: 10.1056/NEJMra1004418.
Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures.
N Engl J Med. 1985 Jul 18;313(3):145-51.
Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy. UK Lamotrigine/Carbamazepine Monotherapy Trial Group.
Lancet. 1995 Feb 25;345(8948):476-9.
A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures.
N Engl J Med. 1990 Aug 23;323(8):497-502.
The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial.
Lancet. 2007 Mar 24;369(9566):1000-15.
Outcomes after seizure recurrence in people with well-controlled epilepsy and the factors that influence it. The MRC Antiepileptic Drug Withdrawal Group.
Epilepsia. 1996 Nov;37(11):1043-50.
Immediate versus deferred antiepileptic drug treatment for early epilepsy and single seizures: a randomised controlled trial.
Lancet. 2005 Jun 11-17;365(9476):2007-13.
Remission of epilepsy. The NGPS. National General Practice Study of Epilepsy.
Lancet. 1995 Nov 4;346(8984):1228.
New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine.
Neurology. 2005. 14;64(11):1868-73.

Epidemiology

Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984.
Epilepsia 1993;34:453-68
Seizures after head trauma: a population study.
Neurology. 1980 Jul;30(7 Pt 1):683-9.
Article must be requested from library, available in print collection.

Epilepsy Surgery

Surgery for seizures.
N Engl J Med. 1996 Mar 7;334(10):647-52.
Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial.
JAMA 2012; 307 (9): 922-930.
A randomized, controlled trial of surgery for temporal-lobe epilepsy.
N Engl J Med. 2001 Aug 2;345(5):311-8.
Vagus nerve stimulation therapy for partial-onset seizures: a randomized active-control trial.
Neurology. 1998 Jul;51(1):48-55.
Successful surgery for epilepsy due to early brain lesions despite generalized EEG findings.
Neurology. 2007 Jul 24;69(4):389-97.

Status Epilepticus/cEEG

A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group.
N Engl J Med. 1998 Sep 17;339(12):792-8.
RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): a double-blind randomized clinical trial of the efficacy of intramuscular midazolam versus intravenous lorazepam in the prehospital treatment of status epilepticus by paramedics.
Epilepsia. 2011 Oct;52 Suppl 8:45-7. doi: 10.1111/j.1528-1167.2011.03235.x.
Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial.
JAMA. 2014 Apr 23-30;311(16):1652-60. doi: 10.1001/jama.2014.2625.
A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia.
Neurology. 1996 Apr;46(4):1029-35.
A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus.
N Engl J Med. 2001 Aug 30;345(9):631-7.
Detection of electrographic seizures with continuous EEG monitoring in critically ill patients.
Neurology. 2004 May 25;62(10):1743-8.
Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial
Lancet. 2020 Apr 11;395(10231):1217-1224.

Women & Epilepsy

Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study.
Lancet Neurol. 2013 Mar;12(3):244-52. doi: 10.1016/S1474-4422(12)70323-X.
Progesterone vs placebo therapy for women with epilepsy: A randomized clinical trial.
Neurology. 2012 Jun 12;78(24):1959-66. doi: 10.1212/WNL.0b013e318259e1f9.
Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry.
Lancet Neurol. 2018 Jun;17(6):530-538. doi: 10.1016/S1474-4422(18)30107-8.

Semiology

Lateralizing signs in intractable partial epilepsy: blinded multiple-observer analysis.
Neurology. 1993 Dec;43(12):2519-25.
Article must be requested from library, available in print collection.
Lateralizing signs during seizures in focal epilepsy.
Epilepsy Behav. 2005 Aug;7(1):1-17.
Localizing and lateralizing features of auras and seizures.
Epilepsy Behav. 2011 Feb;20(2):160-6. doi: 10.1016/j.yebeh.2010.08.034.
Semiological seizure classification.
Epilepsia. 1998 Sep;39(9):1006-13.

Pediatric

Prognosis in children with febrile seizures.
Pediatrics. 1978 May;61(5):720-7.
Article must be requested from library, available in print collection.
Predictors of epilepsy in children who have experienced febrile seizures.
N Engl J Med. 1976 Nov 4;295(19):1029-33.
Response to treatment in a prospective national infantile spasms cohort.
Ann Neurol. 2016 Mar;79(3):475-84. doi: 10.1002/ana.24594.
MRI abnormalities following febrile status epilepticus in children: the FEBSTAT study.
Neurology. 2012 Aug 28;79(9):871-7.
Emergency management of febrile status epilepticus: results of the FEBSTAT study.
Neurology. 2012 Aug 28;79(9):871-7.
Surgery for intractable infantile spasms: neuroimaging perspectives.
Epilepsia. 1993 Jul-Aug;34(4):764-71.

Pathology

An international consensus classification for focal cortical dysplasias.
Lancet Neurol. 2011 Jan;10(1):26-7. doi: 10.1016/S1474-4422(10)70225-8.

Epilepsy: Landmark Articles

Medical Management

Epidemiology

Epilepsy Surgery

Status Epilepticus/cEEG

Women & Epilepsy

Semiology

Pediatric

Pathology

Additional Recommendations