Advances in Molecular Pathology
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The present work corresponds to a compilation of independent contributions in the fields of endocrinology, immunity, cancer, neurobiology, and myology. Revision of current advances as well as novel findings in the form of original articles are presented in a balanced fashion. The book has been divided into three sections in line with the main subject: Molecular pathology of immune, inflammatory, and hemostatic disorders; Molecular pathology of endocrine and muscular disorders; and Molecular pathology of cancer: determinants and potential therapies. In the first section, contributing authors take the reader through the molecular pathology of immune responses, inflammation, and hemostasis, by collating an update on systemic autoimmune diseases, the therapeutic potential of statins in hemostasis, the effects of adrenergic stimulation on coagulation, the emerging field of physical burnout due to the mobility restrictions in response to the 2020 SARS-CoV-2 pandemic imposed worldwide, and the success of community-oriented muscular kinesic rehabilitation. The second section presents engaging results from a survey of iodine intake through the diet of pregnant females, an appraisal of the neuroprotective effect of dexmedetomidine, novel evidence on muscle physiopathology, describing the upregulation of CCL5/RANTES during cholestatic liver disease, the fibrotic response emerging in response to cholic and deoxycholic acids, and the altering effects of bile acids in autophagy and mitogenesis. In the third section, a comprehensive revision of cancer literature is offered with an emphasis on melanoma, myeloid-derived suppressor cells, microRNA-based diagnostic approaches, and new avenues for cancer immunotherapy. Altogether, these individual contributions offer a comprehensive and up-to-date outlook of the current state in the field of molecular pathology. Chapter 14 is available open access under a CreativeCommons Attribution 4.0 International License via link.springer.com.
Congenital Heart Diseases: The Broken Heart : Clinical Features, Human Genetics and Molecular Pathways
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This 2nd edition has been extensively updated and provides comprehensive and current insight into congenital heart diseases, from embryonic development through to clinical features, including human genetics and our current knowledge of the underlying molecular pathways. The book is divided into three parts: an introduction to the development of the heart and its vessels, an overview of the molecular pathways affecting the development of various cardiovascular structures, and a main section focusing on the different types of structural and nonstructural congenital heart diseases, including their clinical features, underlying genetic alterations and insights from animal models and pathways. All chapters have been updated and new chapters added on state-of-the-art approaches including stem cells and organoids, cardiac metabolism, single cell transcriptomics and 3D reconstruction of human heart development. The clinical chapters have been extended and include new sections on diagnostic imaging techniques. Taken together, the book, written by and for clinicians and researchers, provides an integrated and up-to-date resource for all those who want to learn more about both the clinical aspects and the genetic and molecular basis of congenital heart disease. Chapter 11 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
GeNeDis 2022
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The 5th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2022) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. This volume focuses on the sessions from the conference on Molecular Biology, Chemical Biology, and Cellular Biology.
Molecular Biology and Clinical Medicine in the Age of Politicization
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Molecular Biology and Clinical Medicine in the Age of Politicization, Volume 188 provides readers with an appreciation of the practical effects of the politicization of science on their work. Topics covered in the volume include Shattered Silos: Politicization of Science through Changing Research Norms, Moralized Science Communication (with applications for molecular biologists), Vax Attacks: How Conspiratorial Thinking and Misinformation Undermines COVID-19 Vaccine Uptake, Effects of Politicized Media Coverage: Experiment Evidence on Mammography, HPV, and Covid-19, Communicating CRISPR: Challenges and Opportunities in Engaging the Public, Strategic Communication and Engagement for the Biomedical Sciences, and more.Additional chapters cover The Great and Powerful Oz: On the Authority and Misuse of Science, The Gateway-Belief Model and the Politicization of Climate Science, Effects of Politicization on the Practice of Science, When Politics Trumps Science, The Effect of Media Framing and Politics on Covid-19 Vaccine Hesitancy, and more.- Provides reviews from selected experts on the social forces that can limit the impact of science- Highlights its relevance to practitioners of science- Presents the latest insights for molecular biologists in an age of science politicization
Molecular Medicine and Biomedical Research in the Era of Precision Medicine
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Molecular Medicine and Biomedical Research in the Era of Precision Medicine: New Technologies and Personalized Drug Therapies for Patient Care provides researchers with an extensive overview of recent advances in molecular biology impacting the development of targeted therapies. The book delivers insights into the pathobiological and pathogenetic mechanisms of various diseases, providing a detailed study of the latest personalized interventions to be implemented across such conditions. It covers a range of technologies, including RNA-sequencing, AI, Machine Learning, gene therapy, omics and nanotechnology, delving into their clinical applications across various diseases.The book also tackles targeted treatments of different disease types, including acute, chronic, infectious and noncommunicable diseases. Future perspectives are also covered, providing an in-depth study across molecular medicine, drug discovery and delivery, disease diagnosis and prevention, and therapeutic interventions, and acting as an invaluable interdisciplinary reference for researchers across the biomedical sciences.- Investigates the molecular basis and mechanisms of diseases, including cardiovascular, infectious, and neurological diseases- Presents molecular-based therapeutics for personalized treatment and the diagnosis of various conditions- Considers a range of technologies in the field of biomedicine and molecular medicine, including artificial intelligence and nanotechnology
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